I was wondering this myself with some of the font experiments from the other thread (if the reader is anti-aliasing text).
Which may be to simulate ink-bleed - like a printed page would have, and the mac currently does (I might be reaching for the logic) - but I do think the reader is capable of not anti-aliasing text. Zooming in the image attached - seems to generate no anti-aliasing. And, none of the navigational/annotation menus seems to be anti-aliased.
However, I have not seen anywhere in the settings for the reader a place to turn this on or off.
J
ps. not sure how the LRF/LRX files are encoded; so, not sure how easy/difficult it would be to have this as a firmware update.