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In most cases, yeah.
But, you can *technically* put TTF curves in an OTF.
Meaning, if a font is offered *both* as a TTF and an OTF, then, yeah, the OTF will probably be using CFF.
If it's only offered as an OTF, all bets are off. Except if it's a variable font, in which case it's probably CFF, too. Not that your eReader would know what to do with a VF though ;p.
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