Although this doesn't involve an e-book reader it is related. I recently purchased my first smart phone (from Samsung) and soon found that I didn't care for any of the default typefaces that came with it (one looked a little like Helvetica, another like a Bold Helvetica, and the others looked like a handwritten typeface which bore a slight similarity to Comic Sans), especially when doing text messaging. Also, it uses the selected typeface throughout the smart phone's displays.
In the end, I decided to purchase some typefaces for my phone and came upon ITCAmericanType which looks a bit like a proportional-spaced Courier New. I found it a major improvement due to it being very readable, and it made using my phone much more enjoyable.
Returning to the topic of e-books, for the main text of an e-book I prefer a serif typeface (like Times New Roman), while I prefer a sans serif typeface (like Calibri) for other e-book elements (like chapter headings) when I can choose the typeface. But when if it's a purchased e-book I usually just take what options are available.
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