If these are not CBZ/CBR files then converting to greyscale probably isn't going to help much overall. If these are CBZ/CBR files then transcoding may be beneficial. Or it might not. There's very much an "it depends" involved. But for the most part I get good results with ImageMagick:
Code:
KX=1440; KY=1920
GREY="-type Grayscale -level 0%,100%,0.6"
BLUR="-gaussian-blur 0.05"
TRIM="-trim +repage"
FUZZ="-fuzz 1%"
mogrify -verbose -strip -format jpg -quality 85% ${FUZZ} ${TRIM} ${BLUR} -filter Lanczos -resize ${KX}x${KY} ${GREY} *
But realistically? I read my comics and manga on my iPad Mini now.