Calibre users, why don't you use koreader?
IMO it's not either/or, but more about "do you want to use a PC?". If you're managing library on desktop computer - ie making small edits/format conversion to books, organizing huge folders, calibre is hands down the way to go, except maybe if you just need a no-frills book viewer on pc, use Sumatra.
However I have ~1k books and about 100 manga volumes on reader device at any given time. Works fine just with on-device folders, labels and fulltext. Calibre desktop almost never gets involved unless I need to do something fairly obscure, like reflow a PDF.
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