I can't, in good conscience, recommend neophytes disabling Mend on Open/Save. It's one thing for those who know exactly what they're doing, but bad things can happen to those who don't know all the ramifications of trying to save/open invalid xhtml.
Heck, I know exactly what I'm doing, and the only time I disable either one of them is when I'm testing what might go wrong for those who
do.