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Just to toss in my 2¢'s worth. For ebooks I'm editing for my own use, I will use whatever I know works on my collections of applications and ereaders. When I am helping someone else, I very deliberately make KISS the mantra to make it easier to have the ebook look decent on as many platforms as possible. And please note that is not look the best since the last time I went that route, we ended up with 5 versions of the final product and I started a hate affair with media queries of any flavour.
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