My Nook has a pixel defect. It is very small and is right up against the bezel so I didn't even see it for 4 days, and I was looking for it. I decided not to return it because my local store was out of stock at the time. It doesn't bother me.
I have quite a few sideloaded books on mine (not sure how many). Some are from Amazon and some from Kobo and some from Christianbook.com. I haven't had any problems with sideloaded content at all.
I can't help with pdf because I don't have any. Overall, I am very happy with my Nook.
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