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In my unscientific experience, the differences between using sleep/wake cover and actually powering off is not very significant over a 2 week period. Not using a sleep/wake cover, especially if you are picking your book up several times a day, does have more loss of energy over the same period. Keep in mind, in sleep mode, your unit is still hooked to wifi. This allows overnight updates as well as subscription download. If you have wifi totally turned off, I doubt there is much difference between sleep/wake and fully turned off over 2 week period.
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