I've running calibre with Windows Pro and Home since 08.06.2019 with build 1903 (Build 18362.207)and in VM's too. On the Pro machine I add last week about 1.5k new documents via autoadd on one of my bigger libraries. This is a task thats is running twice a month. Ok so fare with no problems.
Had you already check wether a new admin user account make a difference? Guess, if that wont' help you need to setup your system from scratch as you have already done most repair actions, but maybe it is worth it to check windows Fix-It-Tools before.
An additional point is maybe to check the windows update log via powershell (Get-WindowsUpdateLog) wether there was something going wrong during the update process.
Good luck...
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