I can't think of a reason for that to happen. I have calibre doing a backup of the database for every connection, and that only takes a few seconds. The Glo HD is the device I have most trouble with. It is very fussy about the cable and won't work properly with the cable I use for all the other devices. And just testing, it took 12 seconds to back it up and zip it. And it's size is about 150MB.
How big is the database? That will affect the time taken to copy the file. Does the antivirus scan it? That could also slow things down.
And for curiosity, how much space does the compress recover? I haven't seen it do enough to really make it worth doing frequently.
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