For anything short-term there would only be in addition to, not instead of. (E.g. my proof of concept effort that allows for using MuPDF as an alternative EPUB/FB2 renderer.) To my knowledge no one is seriously looking into adding another rendering engine at this time.
Readium wasn't really a thing until post-2013, so by definition it couldn't even have been considered back in 2011/2012.
@houqp wrote up a little something about the history of it somewhere in a GH issue I believe… but I can't seem to find it right this instance.
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