Well, you prefer scrolling over paginated so that's a major plus for LCD already. Also, PDF + 6" e-ink isn't a particularly good combo regardless of software.
I read on both LCD and e-ink. I read epub/mobi and prefer paginated and e-ink works fine for those. I used to find page refresh on (old) e-ink devices too slow but that hasn't been an issue in years. I tend to gravitate towards LCD when convenience is paramount: fast/easy browsing, can buy from any ebook store and read right away (no need to dedrm/convert), can read fanfics directly in-browser.
When I get migraines though, LCD's an absolute no-go whereas I can still tolerate frontlit e-ink and paper (very dim lighting).
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