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Ambiguous vampires have been around for a while - Ann Rice's vampires spring to mind. (I see Catlady beat me to it but posting anyway.) Redeemed bad-people of various sorts have been around for a very long time - various parables in the bible spring to mind (eg: the prodigal son). Redemption and atonement is a fairly common theme in fiction. So I don't see Buffy - but then I only ever saw the movie, not the series.
But, yes, Silas and the whole Honour Guard thing seems like a possible hook for a future story. But only maybe. Gaiman has made quite a habit of alluding to large backstories and then never (yet) coming back to them. It's quite refreshing compared to many other authors that create the one world and continue to exploit just that one for their career.
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