Yes there could be many reasons. For my situation, I am running Windows 10 Pro and the Calibre had no issues until an update last month (don't remember which version). Every time I started it, it just hung at the "Initializing User Interface" screen. I tried uninstall/reinstall, 32 bit/64 bit, nothing worked except for the portable version which I used for a couple weeks. But it still bugged me a bit why it didn't work.
Deleting AppData\roaming\calibre does work and it makes sense too. Some old stuff there was not compatible with the update.
Hope this post will help somebody in the future.
UPDATE: only delete gui.json under AppData\roaming\calibre is good enough for me.
Last edited by mdhuang; 04-21-2019 at 04:34 PM.
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