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Or just put noscript or uMatrix in a Firefox or Waterfox browser and actually turn off all AV except turn it on before insertion of a USB stick, USB HDD drive or CD/DVD etc.
You can still scan downloads before use.
How does malware get on a computer? Either via the Web Browser or plugged in storage. The idea of "real time" scanning or folder protection does little and with those settings the biggest risk is the AV software breaking something after a "definitions update". All AV software is poor, slows the computer a lot and has little to no protection from Zero Day Exploits. Disabling all autorun and blocking third party scripts using noscript or uMatrix in a web browser is better. Also important is to disable uPNP, especially on your Internet modem/router box. If you only use Mobile to connect to the Internet get a Router/Modem that takes the 3G/4G USB stick and then you have a proper firewall and port protection.
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