Have you run Calibre in DEBUG mode, then saved and reviewed the log it produces? It may show nothing even if it should (false negative), but doing so is part of due-diligence.
Have you looked in the Windows 10 'Event Viewer' application on the Start Menu for anything suspicious or possibly correlated?
Have you run Task Manager prior to running Calibre and then performing the actions that you described while taking careful note of any DOS Tasks that appear suddenly?
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