I couldn't open the config folder the way you suggested because I couldn't start calibre, but I was able to do a file search and found the tweaks.py file (in \AppData\Roaming\calibre\). I edited it as you suggested and calibre is now running again - THANKS!!!
At one point in my struggles last night I removed & reinstalled calibre and it didn't fix my problem, so apparently the Remove option in the installation msi removes the application but doesn't clean out the calibre stuff from the AppData areas. I'm guessing that's intentional to save a user's settings, customizations, etc so they're not starting over from scratch if they re-install. For files like this tweaks file that can crash the app if they're corrupted, it might be better to rename & replace them with the standard files on either the removal or re-installation of the app.
Thanks again for the help!
Mark
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