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Originally Posted by Deskisamess
It's my understanding that print replica books are many times textbook type books, or those with equations and formulas that don't work well in a flowable text format.
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From what I've seen published in epub3 fixed layout, illustrated children's book especially those with read-aloud, books that contain a large number of illustrations with captions and sheet music are also prime candidates for fixed layout. The catch is that if you have limited vision or a small screen device, they just don't work that well. Pretty much the same limitations as you can read PDF files on a small screen device but you need a masochistic streak to do on a regular basis.