Considering that the creator of the Access Aide plugin (and several other plugins) uses a Mac for development, I can safely say that it
should work.
Having said that ... you should probably bring up your specific issues in the dedicated threads for each of those plugins. They're found in the
Plugin section of the Sigil forums. There's an alphabetical plugin index list in the sticky area there. The more details, the better. Make sure you include exact warning/error messages you're getting.