I could look for all "big" tags and replace each with a span tag with an inline style attribute style="font-size:larger" but many people do not like inline styles even if they are technically correct.
That said, no conversion can be perfect all of the time, so running epub-check after conversion can easily detect this case, and allow the user to fix it the way they wish.
I will look into auto replacement of big tags with spans and inline styles for the next release of epub-itizer.
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