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I don't run Mojave, and for that matter rarely run calibre on my Macs, but since I run Macs at work I follow various Mac orientated forums.
From what I've seen, there seems to be a change in the font smoothing that Apple uses. From the posts I've seen, the issue is at the OS level and not something that apps need to adjust for. Also, the problem seems to be more significant on non-Retina displays, based on the posts I've seen.
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