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Multi column was invented to simplify mechanical typesetting and for wider pages (newspapers, magazines). I find it horrible even in books (the Bible is the only common book I can think of set in more than one column and single column versions exist now).
Why do you want it on eBooks? Or is a publisher foisting it on you? Unless the eReader is about 8" minimum and 250dpi or better I can't see it working well. The cheaper 6" ereaders are not big enough and often only about 167 dpi to 200 dpi (?), like fax resolution.
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