I'd be pretty surprised if it worked in general. Most EPUB readers typically block access to files on the local filesystem for security reasons -- I know the calibre viewer/editor do that for files accessed via javascript. I cant recall if it is also the case for files not accessed via javascript, but I would not be surprised if it were so.
If you want to view all your books witha particular stylesheet applied, the way to do it is to add it as a "user stylesheet" in the viewer preferences.
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