Hello All:
I had the same problem. Bitdefender has a "feature" (this caused me a lot of frustration until I found out about it) named "Safe Files" which will protect user directories by default. Excluding the Calibre directory in Bitdefender Anti-Virus will not resolve the issue.
Rather than uninstalling Bitdefender, you can give Calibre access to the "Safe Files" by (in Bitdefender Total Security 2018) Opening Bitdefender, going to "View Features>SAFE FILES>Application Access" and clicking the switch next to "calibre.exe" so that it reads "Allowed."
Hopefully this will resolve the issue for any of you Bitdefender users out there.
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