No. I mostly buy eBooks from Amazon and, when I want to read on one of the other (ePub) eReaders (I have too many), I just convert to ePub from AZW3. Usually it gives me a chance to improve on the layout. AZW3 to ePub almost always goes smoothly. As a matter of fact, if I've still got .mobi books that I want to convert to ePub, I find it usually helps to convert them to AZW3 first, then convert them to ePub. I've run into that a couple times with KePub books also. When the chapter is broken up by graphic art images, I find that a KePub converted to directly ePub when moving to the library (in Calibre) will sometimes truncate a few lines before the graphic (when moved to eReaders, not in Calibre itself). Converting to AZW3 then back to ePub gets rid of the graphic (still leaves the extra spaces break) and doesn't truncate the text. (This may be something I'm doing wrong.)
At any rate, I don't think you'll have any problems. Moving from AZW3 to ePub has always been successful for me. I like to embed my favorite font (now Deja Vu Serif E-Ink) and set the line spacing to 135%. The margins I use for 6" readers are top 5, left and right, 9 and bottom, 1. For my 5" readers left and right margins are changed to 7 instead.
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