I did at first assume it was a hardware issue. But changing cables didn't help, and I use other devices on the same USB ports without a problem. I don't have another Kobo to test swapping that out, unfortunately. Eventually I realized that it always happened when Calibre was trying to backup the database and never any other time.
Just now I did a manual copy of the database file to my desktop, and that worked without a hitch. But then I had Calibre do a backup and that also worked, so I guess it wasn't a good comparison. I feel like the problem occurs maybe 75% of the time, though, so I'll see if I can figure out anything else next time.
And I'll look up those other reports of Mac connection problems. Thanks for the tip.
-Tandava
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