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I just finished up Adrian Tchaikovsky's Children of Time, and it was both thoughtful and a lot of fun, if a touch misanthropic. The stumbling block for the OP (who obviously isn't around anymore), would be likable characters. They're in there, but the question at the heart of the novel is whether humanity deserves to survive in the first place, and what it would take for us to get over our destructive tendencies. So, no one in the book is without flaws.
Still, there are strong leads (and arguably villains) of both sexes, and it's both sci-fi and post-apocalyptic from an author who has mostly written fantasy. It operates on something like a 2500 year timescale, but has at least three sets of main characters throughout, each experiencing that span in different ways.
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