Control Panel->Indexing Options will show status
I run 2 AVs (Defender and Malwarebytes) and 2 Search Indexers (Windows Search (WS) and X1). I do not exclude anything from the AV scanners, and all my data folders (including calibre libraries) are included in the indexers.
My textual ebooks either have DOCX, PDF or both formats. DOCX and PDF get completely indexed by WS and X1, which is why I keep the DOCX/PDF formats.
I experience no significant delays.
BR