I've never hit any "hard limits" as you may have done, but I've certainly hit the limits of what's practical to work with on many occasions. I'd suggest that you split the book into the appropriate number of "volumes", as I've done for many of my omnibus editions. I find that once you get beyond a certain size (about 2000 pages, with the window size I work with in BD) it gets very slow and takes forever to build the book.
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