I long ago gave up on drop-caps, favoring instead boldface faux small caps. But it is quite commonly done in print books to ignore any preceding non-alphabet character. Almost always this is a quotation mark. Since there is going to be a close-quote and probably a he said / she said sort of thing, that doesn't seems to bother many readers, if any.
Chicago Manual, 13.37: "When the first word ... opens with [a drop-cap], and this letter belongs to the beginning of a run-in quotation, the opening quotation mark is often omitted."
I realize that you are using the drop-cap more lavishly and for a different purpose, but my feeling is that you are overdoing it.
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