I take calcium and D3 because of a diagnosis of osteopenia in my early 40s. As the osteopenia had reversed by my next bone scan I can conclude that I actually needed one or both. I take a multivitamin when dieting as it is almost impossible to cover your bases when reducing calories.
Other than those I have a supplement that I don't take despite strong doctor recommendation. I didn't see any improvement in my dry-eye from taking fish oil pills she recommended and since they taste nasty I only take them for a week before my check-ups so I can fib to the optometrist.