One under-explored factor in this discussion certain types of people are far more likely to be viewed as safe to interrupt. Some of the posts regarding wheelchair users have touched on this, but I think it's worth saying straight out. People with visible disabilities, young or pregnant women, etc, are far more likely to be interrupted than a business-like middle-aged man or someone dressed to project an air of aggression, and also more likely to have people take visible offense when we don't react like the interrupter expects.
That informs our reactions to interruptions. When they're a rare occurrence it's much easier to blow them off.
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