I will occasionally start up a conversation with a person next to me in line at the post office, grocery store, etc., but if they are obviously not interested in continuing the conversation I will leave them alone. I see no point in annoying someone who is perhaps already having a bad day and just trying to get their errands done.
I rarely travel so the plane isn't a likely situation for me, but If I were seated next to someone on a plane who was obviously reading I wouldn't try to converse with them beyond perhaps a brief greeting.
I certainly wouldn't get in the way of a person in a wheelchair and prevent them from moving just so I could make a stupid joke.
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