@Zalbag - Kovid added a built-in OpenWith feature to calibre a while back, IMO it's easier to configure/use than the plugin.
Easiest way to configure it is to right click on a format in the book details panel, e.g. EPUB, PDF, MOBI etc. Easiest way to use it is via keyboard shortcuts you assign in Preferences->Keyboard, and/or via the View specific format feature.
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