Go to Settings - Reading Settings and uncheck the box labelled 'Show Adobe EPUB page numbers'.
That will remove the numbers down the right-hand side leaving only the page number in the footer.
ETA: If you are talking about page numbers interspersed with your book text, this sounds like an EPUB which has been badly converted from a PDF. No easy answers for this one other than to find a better source for the book or roll up your sleeves and manually edit the EPUB in an EPUB editor such as Calibre's or Sigil. Expect it to take a long time.
Last edited by jackie_w; 03-14-2018 at 02:51 PM.
Reason: ETA:
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