I can't really remember any books I've read with only one or two leading characters...
But there's one female lead character I really liked and that is Charis from Taliesin, the first book of the Pendragon Cycle by Stephen R. Lawhead. You follow her from the time she's a vain girl, through several world shattering (literally) events, to her being a grown up woman. She's a female in a time when women weren't that important, and the writer really makes her a woman with a strong spirit, without making her masculine (aka "man with tits").
Frank Herbert also puts his women down as strong persons, who are acutely aware of their femininity.
Thea Beckman (a Dutch writer of young adult and children's books) also knew how to make her women female and yet strong, without ever forcing them into a role they shouldn't have taken considering the environment.
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