@Kythe42 - how do you 'back it up to the hard drive'?
I install and use portable on USB sticks and hard drives on 'stranger' machines quite regularly. I've had a couple of occasions where the host machine (Win 7 or Win10) was configured to prevent execution from external devices, pretty sure I got a message.
I think there's a setting in the Group Policy Editor that comes with Windows Pro edition, for Home edition its a registry hack Ψ²
I've never had to use a BAT file to use portable - just double clicked (or similar) on <whatever>\Calibre Portable\calibre-portable.exe.
BR
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