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I don't know about scientific opinions but only my own experience.
Of course, mine is a very particular case, so I assume it cannot be generalized.
I've made many, many, many tests with colors on my screen (it's well calibrated and not "full brightness" as zelda_pinwheel suggests), and I prefer "inverted colors".
As pilotbob says: "The reason being that the dark background colors project less light and cause less eye strain".
The excessive light of white backgrounds blinds me.
But I don't like "pure" inverted colors, I mean white text on black background. Instead, I use an slightly dimmed white on a mid-dark gray background and it works the best for me.
There are some drawbacks, though. The most of computer programs are intended for white backgrounds and have not only black text but also dark blue, green, red ... Windows XP (I don't know about Vista) and most usual applications (Office, Outlook, Internet Explorer, etc.) don't convert these secondary colors or, even worse, convert only text or only background, so I often get dark blue on dark gray, white on white, or black on dark gray, resulting unreadable. But I have to live with that.
I'm just trying Kubuntu Linux with KDE4. It seems to be much more configurable.
Anyway, As I say at the beginning, this is my personal experience.
Thank you very much for your interest in my troubles.
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