Prettify changes whitespace in an attempt to cleanly indent html code to make it more readable by humans. I typically only use this if I am starting from code that is horrible.
Mend tries to make no whitespace changes and does the absolute minimum to fix broken html.
I personally use mend on open only and that is because gumbo will fix the code so that it is parseable to update links and things when an epub is first opened anyway.
CSS setting is personal preference since epub2 is somewhere between those two CSS specs.
Tidy is no longer part of Sigil because it often ate text.
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