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I haven't followed all your arguments for your case (we no longer have any pre-Windows 10 machines here) but to me, on first flush, I would have thought the following.
If one has confidence that the Calibre package contains no threats (there is no world experience of it doing so and I think it a safe assumption that it doesn't as long as obtained from the official site) and if Calibre starts if you remove Comodo (and all other Comodo products if you are using others), then it would seem to me that it is a Comodo issue and if you wish to remain a user of Comodo products then the matter should be addressed to them.
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