@BetterRed: I don't just suspect version 3.13 of Calibre, because my previous version was pretty old. The reasons I've been focusing on Python rather than other third party libraries such as Qt or libmtp are (1) the error message when Comodo blocked Calibre from launching referred to a Python function terminating unexpectedly, and (2) I didn't know what other third party libraries besides Python were used by Calibre. The Comodo event log's references to attempts to access ".../Tcpip/Parameters" in the Windows Registry is a hint that the function that triggered Comodo was net-related, so hopefully we can eliminate from consideration any libraries that never access the net. (Does Qt ever access the net?) By the way, the version of Windows on my pc is Vista, and where I wrote "..." in the ".../Tcpip/Parameters" string I wasn't being literal; I was eliding part of a much longer string.
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