I have a similar issue: When I try to launch Calibre 3.13 (the latest version, I believe) it fails to launch and displays an error window: "Python function terminated unexpectedly / DLL load failed: A dynamic link library (DLL) initialization routine failed. (Error Code: 1)" However, if I launch calibre-debug -g instead of calibre, calibre launches successfully (along with a separate cmd.exe window that displays some debugging info). Hopefully this will provide a hint to the developer to let him find and fix the issue, and in the meantime will show users how to work around the problem.
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