Quote:
Originally Posted by theducks
Windows Defender plays nice with Calibre unless you have customized it  in some unusual way.
I would look at some 'helper utilities' that you may have installed. Note: they don't need to be of the Malware kind, they just don't play nice.
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Thanks to all of you who helped me on this one. Yes, it was in fact something blocking the Calibre files, and yes, it was in fact Defender! Turns out it was a new feature in Defender that shipped with the latest Fall Creators Update v1709. The feature, which I had forgotten, and which I had enabled is called 'Controlled Folder Access.' It is supposed to help guard against potential ransomware attacks. Anyway, when I realized that this was the blocking agent, I created an exception for Calibre. Once unblocked, I created a new Calibre Library, copied back the book folders into it. And finally I had to use the 'Restore Database' tool in Calibre. Now all's well again.
You guys at MobileRead rock! Couldn't have done it without your help.