Quote:
Originally Posted by rfcdvc45
Thanks for responding, however that's not much help. As I said, the only antivirus I am running is Windows Defender which is pretty much baked into Windows 10. The only way to disable it is to install a third party antivirus. I can't think of any other thing that could be blocking the opening of the metadata.db file.
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Windows Defender plays nice with Calibre unless you have
customized it

in some unusual way.
I would look at some 'helper utilities' that you may have installed. Note: they don't need to be of the Malware kind, they just don't play nice.