Sounds like a slowly failing HD.
Also even though you disabled Kaspersky, it still might be Kaspersky. Try adding a directory exception to your calibre library, or uninstalling Kaspersky completely as a temporary test (just reinstall it right after). I've seen many AVs that cause issues with software that don't resolve themselves from disabling it, only removal.
Last edited by BaronKrause; 10-01-2017 at 03:54 PM.
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