Quote:
Originally Posted by yogi62
Today the initialization took 4min 21 secs. Shutting down and restarting Calibre took 10 secs on two subsequent re-starts.
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Something is still wrong. 4min (even if it is just a first start)

Something appears to be caching the program during that first start or you A/V is checking the program, then whitelisting that runtime version.
I run on a
slowly 
, core 2 duo, (16G RAM) and Calibre still starts up in well under a minute.