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Originally Posted by BetterRed
@JSWolf - trying Compatibility mode and Run as administrator can each be done in a couple of minutes with a couple of clicks, without doing a restart - if either works then that might give a clue as where the problem lies.
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True. It won't take long to try these things out.
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Disabling everything that can be disabled is a much bigger task and it will require restarts. In the case of disabling services it's potentially dangerous, the system might not restart. Before doing anything along these lines you'd want to make sure a) you had a current bootable backup on a thumb drive or DVD, and b) you've tested it. In short it could be hours of 'work'.
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The only things to disable would be third party services and you'd also have to disable all third party programs from running. I'm not suggesting to disable OS services because that won't help as they aren't the issue.
There's one other thing that can be tried. Uninstall all the third party software you can instead of disabling the services/programs from running. They can be re-installed later.
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A better approach in this instance might be to create VM and install calibre in it, rather than crippling a working system. Assuming calibre works in the VM, one would then progressively add one's 3rd party software to it. Eventually, hopefully, calibre won't start, one would then go into the real machine and exorcise that item and verify calibre will now start - hopefully
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Where would one get Windows 10 Creator Update to install in a VM without paying for it?