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@JSWolf - trying Compatibility mode and Run as administrator can each be done in a couple of minutes with a couple of clicks, without doing a restart - if either works then that might give a clue as where the problem lies.
Disabling everything that can be disabled is a much bigger task and it will require restarts. In the case of disabling services it's potentially dangerous, the system might not restart. Before doing anything along these lines you'd want to make sure a) you had a current bootable backup on a thumb drive or DVD, and b) you've tested it. In short it could be hours of 'work'.
A better approach in this instance might be to create VM and install calibre in it, rather than crippling a working system. Assuming calibre works in the VM, one would then progressively add one's 3rd party software to it. Eventually, hopefully, calibre won't start, one would then go into the real machine and exorcise that item and verify calibre will now start - hopefully.
BR
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