@JSWolf - I used the -ignoreplugings thingee and Calibre still is glitchy.
@kovidgoyal - How specifically do I do that? I think I'll have to go back in safe mode and carry out further investigation.
Question - Is the MDE meant to freeze slightly on an empty "Tag" field when cycling through using the next button??
@BetterRed - You're proably right - the tech forgot something

. Everything else seems to be working okay. If I didn't have the comparison with calibre on XP, I wouldn't have thought any different here.
That --ignoreplugins did the job, but still gltichy without them present. Safe mode seemed to show with them still present Calibre was working okay. More testing is required in safe mode.
Ccleaner has shown me a number of programs that I'll disbable and see what happens. Never looked at that portion of CC before.
AS for the desktop in safe mode - it was the resolutions setting was different maybe 800x600 or something - made it look weird. Didn't want to change anything in case I got stuck with it. My actual desktop is clean.
I'm on holiday at present (almost over

) and we're out again today, so I probably won't get a lot of time to investigate.
Really appreciate the help. Playing in areas of the win software I haven't been in before is scary. Always worried I'll mess something up. Got enough damn problems!